Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29834964 | 0.79 | IRAK4 (0.43) | IRAK4HTR7CHRNB2CHRNA4HTR1A | |
| SCHEMBL1555528 | 0.79 | IRAK4 (0.43) | IRAK4HTR7CHRNB2CHRNA4HTR1A | |
| SCHEMBL10322640 | 0.76 | MMP8 (0.45) | IRAK4CYP1A2CHRNB2CHRNA4MEN1 | |
| SCHEMBL31096150 | 0.75 | CYP1A2 (0.44) | IRAK4CYP1A2CHRNB2CHRNA4MEN1 | |
| SCHEMBL21823474 | 0.75 | CYP1A2 (0.44) | IRAK4CYP1A2CHRNB2CHRNA4MEN1 | |
| SCHEMBL26477557 | 0.75 | CYP1A2 (0.44) | IRAK4CYP1A2CHRNB2CHRNA4MEN1 | |
| SCHEMBL24713780 | 0.75 | IRAK4 (0.43) | IRAK4HTR7CHRNB2CHRNA4HTR1A | |
| SCHEMBL13550092 | 0.74 | KDM4E (0.52) | CYP1A2BCHEACHEPTGS2KMT2A | |
| SCHEMBL21381388 | 0.74 | CYP1A2 (0.42) | IRAK4CYP1A2CHRNB2CHRNA4MEN1 | |
| SCHEMBL30415289 | 0.74 | CYP1A2 (0.42) | IRAK4CYP1A2CHRNB2CHRNA4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528149-B2 | Respiratory syncytial virus replication inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-05 | — | — | US | disclosed |
| US-20070135404-A1 | Respiratory Syncytial Virus Replication Inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-06-14 | — | — | US | disclosed |
| US-7179811-B2 | Respiratory syncytial virus replication inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-02-20 | — | — | US | disclosed |
| US-20070015747-A1 | RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS | JANSSEN PHARMACEUTICA, N.V. | 2007-01-18 | — | — | US | disclosed |
| CN-1210275-C | Respiratory syncytial virus replication inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-07-13 | — | — | CN | disclosed |
| US-6747028-B1 | 1,2-SUBSTITUTED BENZIMIDAZOLES HAVING ANTIVIRAL ACTIVITY | HANSSEN PHARMACEUTICA, N.V. (BE) | 2004-06-08 | — | — | US | disclosed |
| EP-1196409-B1 | RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2004-02-04 | — | — | EP | disclosed |
| CN-1358181-A | Respiratory syncytial virus replication inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2002-07-10 | — | — | CN | disclosed |
| EP-1196409-A2 | RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001000612-A2 | RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135404-A1 | Respiratory Syncytial Virus Replication Inhibitors | SARS1, ACE, MAVS | IRAK4 2267/4885HTR7 3960/4885CYP1A2 1172/4885 |
| US-20070015747-A1 | RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS | SARS1, ACE, MAVS | IRAK4 2267/4885HTR7 3960/4885CYP1A2 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.