Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 5/20 | 0.35 |
| ▸ | PTGFR | P43088 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233697 | 0.83 | PTGES (0.36) | EPHX1PTGES | |
| SCHEMBL232740 | 0.76 | KDM4E (0.32) | — | |
| SCHEMBL17891946 | 0.74 | CA1 (0.36) | PTGFR | |
| SCHEMBL3869907 | 0.72 | FFAR1 (0.37) | PTGESHRH3 | |
| SCHEMBL236286 | 0.72 | EPHX1 (0.37) | EPHX1PTGES | |
| SCHEMBL3859047 | 0.72 | MAP3K14 (0.39) | — | |
| SCHEMBL21826348 | 0.71 | SLC18A3 (0.40) | — | |
| SCHEMBL21826347 | 0.71 | SLC18A3 (0.40) | — | |
| SCHEMBL21826350 | 0.71 | SLC18A3 (0.40) | — | |
| SCHEMBL3860771 | 0.71 | HTT (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |