Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3858481 | 0.88 | ASIC3 (0.43) | FFAR1HRH3CYP2D6EGFR | |
| SCHEMBL3865719 | 0.86 | HTR2C (0.42) | FFAR1ALDH1A1HRH3CYP2D6EGFR | |
| SCHEMBL3868238 | 0.85 | HTR2C (0.46) | ALDH1A1HRH3CYP2D6EGFR | |
| SCHEMBL3864024 | 0.80 | TAAR1 (0.36) | FFAR1HRH3CYP2D6 | |
| SCHEMBL12488285 | 0.80 | MMP12 (0.46) | FFAR1HRH3 | |
| SCHEMBL232872 | 0.78 | TAAR1 (0.40) | FFAR1ALDH1A1MELKCYP2D6 | |
| SCHEMBL3731068 | 0.77 | ENPP2 (0.47) | FFAR1ALDH1A1MELKHRH3 | |
| SCHEMBL1244860 | 0.77 | FFAR1 (0.51) | FFAR1ALDH1A1MELKHRH3CYP2D6 | |
| SCHEMBL3859047 | 0.75 | MAP3K14 (0.39) | ALDH1A1 | |
| SCHEMBL2151068 | 0.74 | CYP2D6 (0.32) | FFAR1HRH3CYP2D6PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |