Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441502 | 0.81 | CES2 (0.50) | CYP3A4TSHRALDH1A1KDM4EMEN1 | |
| SCHEMBL7450293 | 0.76 | CES2 (0.51) | LMNACYP3A4TSHRMAPTALDH1A1 | |
| SCHEMBL10886180 | 0.75 | MAPT (0.42) | LMNACYP1A2CYP3A4TSHRMAPT | |
| SCHEMBL11506938 | 0.72 | HSD17B3 (0.69) | LMNACYP1A2CYP3A4TSHRCYP2C9 | |
| SCHEMBL18806594 | 0.70 | HSD17B3 (0.58) | LMNACYP1A2CYP3A4TSHRCYP2C9 | |
| SCHEMBL18806552 | 0.70 | HSD17B3 (0.58) | LMNACYP1A2CYP3A4TSHRCYP2C9 | |
| SCHEMBL18806571 | 0.70 | HSD17B3 (0.58) | LMNACYP1A2CYP3A4TSHRCYP2C9 | |
| Octadecanoic Acid Amide SCHEMBL9387430 | 0.69 | SOAT1 (0.57) | LMNACYP1A2CYP3A4TSHRCYP2C9 | |
| SCHEMBL1553413 | 0.69 | CES2 (0.47) | CYP3A4CYP2C19MAPTNPC1RAB9A | |
| Dodecanoate SCHEMBL8366235 | 0.68 | GPR84 (0.68) | LMNACYP1A2TSHRCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560591-B2 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2009-07-14 | — | — | US | disclosed |
| US-20080207764-A1 | Novel Benzamidine Derivatives Having Anti-Inflammatory and Immunosuppressive Activity | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2008-08-28 | — | — | US | disclosed |
| US-20070135523-A1 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity | ROTTA RESEARCH LABORATORIUM S.P.A | 2007-06-14 | — | — | US | disclosed |
| US-7202277-B2 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2007-04-10 | — | — | US | disclosed |
| US-20040110801-A1 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive | ROTTAPHARM BIOTECH S.R.L. (IT) | 2004-06-10 | — | — | US | disclosed |
| EP-1363875-A2 | NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002070468-A2 | NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135523-A1 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity | HRH4, HRH3, HRH2 | LMNA 4562/4885CYP1A2 484/4885CYP3A4 379/4885 |
| US-20080207764-A1 | Novel Benzamidine Derivatives Having Anti-Inflammatory and Immunosuppressive Activity | HRH4, HRH3, HRH2 | LMNA 4621/4885CYP1A2 493/4885CYP3A4 395/4885 |
| US-20040110801-A1 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive | HRH4, NAT1, HRH3 | LMNA 4423/4885CYP1A2 795/4885CYP3A4 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.