Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.57 |
| ▸ | GRM5 | P41594 | 7/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 3/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3869036 | 1.00 | DHODH (0.57) | DHODHGRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL3874215 | 0.90 | CCR2 (0.60) | GRM5L3MBTL1NPC1RAB9ACCR2 | |
| SCHEMBL3874214 | 0.90 | CCR2 (0.60) | GRM5L3MBTL1NPC1RAB9ACCR2 | |
| SCHEMBL6820719 | 0.87 | GRM5 (0.68) | GRM5L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL3872046 | 0.82 | CHRM1 (0.58) | DHODHGRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL3872045 | 0.82 | CHRM1 (0.58) | DHODHGRM5L3MBTL1NPC1RAB9A | |
| SCHEMBL3880147 | 0.79 | CCR2 (0.57) | DHODHCCR2MEN1KMT2A | |
| SCHEMBL3875809 | 0.79 | CCR2 (0.57) | DHODHCCR2MEN1KMT2A | |
| SCHEMBL3875804 | 0.79 | CCR2 (0.57) | DHODHCCR2MEN1KMT2A | |
| SCHEMBL13853130 | 0.77 | DHODH (0.43) | DHODHGRM5L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891064-B1 | N-AMIDE DERIVATIVES OF 8-AZABICYCLO[3.2.1]OCT-3-YL AS CCR1 ANTAGONISTS | ALMIRALL SA (ES) | 2009-09-02 | — | — | EP | disclosed |
| EP-1891064-A1 | N-AMIDE DERIVATIVES OF 8-AZABICYCLO[3.2.1]OCT-3-YL AS CCR1 ANTAGONISTS | Laboratorios Almirall, S.A. (ES) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133802-A1 | N-AMIDE DERIVATIVES OF 8-AZABICYCLO[3.2.1]OCT-3-YL AS CCR1 ANTAGONISTS | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-12-21 | — | — | WO | disclosed |