Sugi Predict

Sugi Predict / Compounds / SCHEMBL3870178

SCHEMBL3870178

SCHEMBL3870178

COc1ccc(Cl)cc1CC(=O)O

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 1/20 0.68
▸ CHRM1 P11229 1/20 0.54
▸ MEN1 O00255 3/20 0.51
▸ KMT2A Q03164 3/20 0.51
▸ MAPT P10636 1/20 0.51
▸ GAA P10253 4/20 0.50
▸ LMNA P02545 2/20 0.50
▸ ADRB2 P07550 1/20 0.49
▸ NPSR1 Q6W5P4 1/20 0.49
▸ KDM4E B2RXH2 1/20 0.48
▸ ALDH1A1 P00352 2/20 0.48
▸ TDP1 Q9NUW8 2/20 0.47
▸ PTGDR2 Q9Y5Y4 2/20 0.47
▸ HPGD P15428 1/20 0.47
▸ TTR P02766 1/20 0.47
▸ PTGDR Q13258 1/20 0.47
▸ KEAP1 Q14145 1/20 0.46
▸ NFE2L2 Q16236 1/20 0.46
▸ TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3876888 0.86 MEN1 (0.51) HSD17B10MEN1KMT2AMAPTGAA
SCHEMBL29531142 0.86 HSD17B10 (0.54) HSD17B10CHRM1MEN1KMT2AGAA
SCHEMBL1678581 0.86 HSD17B10 (0.54) HSD17B10CHRM1MEN1KMT2AGAA
SCHEMBL10864958 0.86 CYP3A4 (0.61) HSD17B10MEN1KMT2AMAPTGAA
SCHEMBL3869208 0.85 MEN1 (0.50) HSD17B10MEN1KMT2AMAPTGAA
SCHEMBL7135010 0.85 MEN1 (0.54) HSD17B10MEN1KMT2AMAPTGAA
SCHEMBL7433243 0.83 FFAR1 (0.50) HSD17B10MEN1KMT2AMAPTGAA
SCHEMBL27355584 0.83 CHRM1 (0.54) HSD17B10CHRM1MAPTTDP1PTGDR2
SCHEMBL3873628 0.82 POLB (0.49) HSD17B10MEN1KMT2AGAALMNA
SCHEMBL3869051 0.82 MEN1 (0.55) HSD17B10MEN1KMT2AGAALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020010204-A1 2- and 2,5-substituted phenylketoenols LIEB FOLKER (DE) 2002-01-24 — — US claimed
US-4390723-A BIS(8-QUINOLINOLATE) COPPER COMPLEX CATALYST IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1983-06-28 — — US claimed
US-20260144743-A1 COMPOUNDS TMEM16A LIMITED (GB) 2026-05-28 — — US disclosed
EP-4699655-A2 COMPOUNDS TMEM16A LIMITED (GB) 2026-02-25 — — EP disclosed
US-12552770-B2 Compounds for treating respiratory disease TMEM16A LIMITED (GB) 2026-02-17 — — US disclosed
EP-4153170-B1 MAXI-K POTASSIUM CHANNEL OPENERS FOR THE TREATMENT OF FRAGILE X ASSOCIATED DISORDERS SERVIER LAB (FR) 2026-01-21 — — EP disclosed
US-12415793-B2 Modulators of TMEM16A for treating respiratory disease TMEM16A LIMITED (GB) 2025-09-16 — — US disclosed
US-12377105-B2 Compounds TMEM16A LIMITED (GB) 2025-08-05 — — US disclosed
US-12281077-B2 Solid forms of n-tert-butyl-4[[2-(5-chloro-2-hydroxy-phenyl)acetyl]amino]pyridine-2-carboxamide TMEM16A LIMITED (GB) 2025-04-22 — — US disclosed
CN-119490451-A Compounds as positive modulators of calcium activated chloride channels TMEM16A有限公司 2025-02-21 — — CN disclosed
CN-114269721-B Compounds for the treatment of respiratory diseases TMEM16A有限公司 2024-12-20 — — CN disclosed
US-5696138-A Urea derivatives and their use NEUROSEARCH A/S (DK) 1997-12-09 — — US disclosed
WO-1997045111-A1 PHENYL DERIVATIVES USEFUL AS BLOCKERS OF CHLORIDE CHANNELS NEUROSEARCH A/S (DK) 1997-12-04 — — WO disclosed
CN-1144800-A 3-ketoindole derivates taken as potassium channels regulator BRISTOL MYERS SQUIBB CO (US) 1997-03-12 — — CN disclosed
US-5602169-A USEFUL IN REDUCING NEURONAL DAMAGE DURING ISCHEMIC STROKE BRISTOL-MYERS SQUIBB COMPANY (US) 1997-02-11 — — US disclosed
EP-0747354-A1 3-Substituted oxindole derivatives as potassium channel modulators BRISTOL-MYERS SQUIBB COMPANY (US) 1996-12-11 — — EP disclosed
US-5565483-A ADMINISTERING AS THERAPY FOR ISCHEMIA, CONVULSIONS OR ASTHMA BRISTOL-MYERS SQUIBB COMPANY (US) 1996-10-15 — — US disclosed
EP-0693053-A1 UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS NEUROSEARCH A/S (DK) 1996-01-24 — — EP disclosed
WO-1994022807-A1 UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS NEUROSEARCH A/S (DK) 1994-10-13 — — WO disclosed
US-4390723-A BIS(8-QUINOLINOLATE) COPPER COMPLEX CATALYST IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1983-06-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260144743-A1 COMPOUNDS CACNA1E, TMEM109, CACNA1C HSD17B10 868/4885CHRM1 493/4885MEN1 1622/4885
US-12552770-B2 Compounds for treating respiratory disease TMEM109, SCN1A, SLC16A1 HSD17B10 1812/4885CHRM1 321/4885MEN1 1176/4885
US-12415793-B2 Modulators of TMEM16A for treating respiratory disease TMEM109, CFTR, TMEM120A HSD17B10 1113/4885CHRM1 486/4885MEN1 1912/4885
US-12281077-B2 Solid forms of n-tert-butyl-4[[2-(5-chloro-2-hydroxy-phenyl)acetyl]amino]pyridine-2-carboxamide NAT1, EP300, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 HSD17B10 3000/4885CHRM1 1338/4885MEN1 3225/4885
US-20020010204-A1 2- and 2,5-substituted phenylketoenols CYP1B1, CYP4X1, CYP1A1 HSD17B10 170/4885CHRM1 698/4885MEN1 4206/4885
US-12377105-B2 Compounds CACNA1E, TMEM109, CACNA1A HSD17B10 2273/4885CHRM1 158/4885MEN1 1146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.