Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 3/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3865994 | 0.85 | MTNR1A (0.40) | OPRK1OPRD1MTNR1AMTNR1BCNR1 | |
| SCHEMBL3869016 | 0.82 | CNR1 (0.36) | OPRK1OPRD1MTNR1AMTNR1BCNR1 | |
| SCHEMBL3861226 | 0.81 | MTNR1A (0.36) | OPRK1OPRD1MTNR1AMTNR1BCNR1 | |
| SCHEMBL236172 | 0.80 | MTNR1A (0.36) | HDAC6OPRK1OPRD1MTNR1AMTNR1B | |
| SCHEMBL235733 | 0.80 | HDAC6 (0.36) | HDAC6OPRK1OPRD1MTNR1AMTNR1B | |
| SCHEMBL235732 | 0.80 | HDAC6 (0.36) | HDAC6OPRK1OPRD1MTNR1AMTNR1B | |
| SCHEMBL13400259 | 0.76 | HDAC6 (0.38) | HDAC6OPRK1OPRD1MTNR1AMTNR1B | |
| SCHEMBL2207058 | 0.76 | SIRT2 (0.42) | — | |
| SCHEMBL13400239 | 0.76 | HDAC6 (0.38) | HDAC6OPRK1OPRD1MTNR1AMTNR1B | |
| SCHEMBL2207061 | 0.76 | SIRT2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |