Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3865994 | 0.91 | MTNR1A (0.40) | CNR1CNR2MTNR1AMTNR1BNQO2 | |
| SCHEMBL3950229 | 0.87 | MTNR1A (0.44) | CNR1CNR2CASROPRM1OPRL1 | |
| SCHEMBL3861226 | 0.86 | MTNR1A (0.36) | CNR1CNR2MTNR1AMTNR1BNQO2 | |
| SCHEMBL236345 | 0.83 | OPRM1 (0.36) | CNR1CNR2CASROPRM1OPRL1 | |
| SCHEMBL3870189 | 0.82 | HDAC6 (0.35) | CNR1CNR2MTNR1AMTNR1BOPRD1 | |
| SCHEMBL4569064 | 0.81 | CNR1 (0.41) | CNR1CNR2MTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL612756 | 0.81 | CNR1 (0.41) | CNR1CNR2MTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL14643104 | 0.79 | MTNR1A (0.40) | CNR1CNR2MTNR1AMTNR1BNQO2 | |
| SCHEMBL3948109 | 0.78 | MTNR1A (0.33) | CNR1CNR2MTNR1AMTNR1BNQO2 | |
| SCHEMBL614318 | 0.78 | MTNR1A (0.44) | CNR1CNR2MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |