SCHEMBL3870286

SCHEMBL3870286

Cc1cccc2c1Nc1ccccc1O2

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 10/20 0.59
TP53 P04637 1/20 0.40
POLB P06746 1/20 0.40
MAPT P10636 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GAA P10253 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
DHODH Q02127 1/20 0.39
PARP1 P09874 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31191637 1.00 ALOX5 (0.59) ALOX5TP53POLBMAPTTDP1
SCHEMBL31618797 0.98 ALOX5 (0.57) ALOX5TP53POLBMAPTTDP1
SCHEMBL30811547 0.86 ALOX5 (0.41) ALOX5MEN1KMT2A
SCHEMBL24484552 0.86 ALOX5 (0.41) ALOX5MEN1KMT2A
SCHEMBL12016686 0.83 CREBBP (0.41) ALOX5
SCHEMBL10980555 0.81 ALOX5 (0.55) ALOX5TP53POLBMAPTTDP1
SCHEMBL10981657 0.81 ALOX5 (0.42) ALOX5MAPTGAAMEN1KMT2A
SCHEMBL11981380 0.79 ALOX5 (0.52) ALOX5TP53POLBMAPTTDP1
SCHEMBL5320399 0.77 ALOX5 (0.59) ALOX5POLBMAPTTDP1GAA
SCHEMBL2724592 0.77 ALOX5 (0.59) ALOX5TP53MAPTGAANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007113644-A2 NEW HDAC INHIBITORS ORCHID RESEARCH LABORATORIES LIMITED (IN) 2007-10-11 WO claimed
CN-115777718-A Use of 3-isoxazolidinone compounds as selective herbicides FMC有限公司 2023-03-14 CN disclosed
CN-115708511-A Use of 3-isoxazolidinone compounds as selective herbicides FMC有限公司 2023-02-24 CN disclosed
CN-115669672-A Use of 3-isoxazolidinone compounds as selective herbicides FMC有限公司 2023-02-03 CN disclosed
CN-106455569-B Use of 3-isoxazolidinone compounds as selective herbicides FMC有限公司 2022-12-09 CN disclosed
EP-3131897-B1 FACTOR IXA INHIBITORS MERCK SHARP & DOHME (US) 2022-06-15 EP disclosed
WO-2020028619-A1 SPARC BASED MICROORGANISM DETECTION METHOD BECKMAN COULTER, INC. (US) 2020-02-06 WO disclosed
EP-3131896-B1 FACTOR IXA INHIBITORS MERCK SHARP & DOHME (US) 2019-01-30 EP disclosed
US-9969724-B2 Factor IXa inhibitors MERCK SHARP & DOHME CORP. (US) 2018-05-15 US disclosed
US-9808445-B2 Factor IXa inhibitors MERCK SHARP & DOHME CORP. (US) 2017-11-07 US disclosed
US-20070027053-A1 Detergent composition comprising coated bleach particle RECKITT BENCKISER N.V. (NL) 2007-02-01 US disclosed
EP-1682646-A1 DETERGENT COMPOSITION COMPRISING COATED BLEACH PARTICLE Reckitt Benckiser N.V. (NL) 2006-07-26 EP disclosed
WO-2005042685-A1 DETERGENT COMPOSITION COMPRISING COATED BLEACH PARTICLE RECKITT BENCKISER N.V. (NL) 2005-05-12 WO disclosed
WO-2002036727-A1 A DETERGENT COMPOSITION COMPRISING A METALLO PROTEASE AND CALCIUM ION THE PROCTER & GAMBLE COMPANY (US) 2002-05-10 WO disclosed
EP-1141199-A1 DETERGENT COMPOSITIONS COMPRISING A PECTATE LYASE AND A SPECIFIC SURFACTANT SYSTEM THE PROCTER & GAMBLE COMPANY (US) 2001-10-10 EP disclosed
WO-2000042155-A1 DETERGENT COMPOSITIONS COMPRISING A PECTATE LYASE AND A SPECIFIC SURFACTANT SYSTEM THE PROCTER & GAMBLE COMPANY (US) 2000-07-20 WO disclosed
EP-0928329-A1 PEROXIDASE VARIANTS NOVO NORDISK A/S (DK) 1999-07-14 EP disclosed
EP-0922088-A1 DETERGENT COMPOSITIONS COMPRISING ANTIBODY CONTROLLED ENZYMATIC ACTIVITY THE PROCTER & GAMBLE COMPANY (US) 1999-06-16 EP disclosed
WO-1998010060-A1 PEROXIDASE VARIANTS NOVO NORDISK A/S (DK) 1998-03-12 WO disclosed
WO-1998006812-A1 DETERGENT COMPOSITIONS COMPRISING ANTIBODY CONTROLLED ENZYMATIC ACTIVITY THE PROCTER & GAMBLE COMPANY (US) 1998-02-19 WO disclosed