Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3870889 | 0.87 | FOXO1 (0.40) | FOXO1STAT3HTTKDM4EALDH1A1 | |
| SCHEMBL5868740 | 0.81 | FOXO1 (0.53) | FOXO1STAT3HTTKDM4EALDH1A1 | |
| SCHEMBL7158963 | 0.80 | KDM4E (0.49) | STAT3KDM4EALDH1A1TDP1HTR3A | |
| SCHEMBL10723280 | 0.78 | TDP1 (0.37) | FOXO1STAT3HTTALDH1A1GSK3B | |
| SCHEMBL3874174 | 0.78 | FOXO1 (0.36) | FOXO1STAT3HTTKDM4EALDH1A1 | |
| SCHEMBL27287068 | 0.76 | STAT3 (0.70) | STAT3HTTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL1344898 | 0.76 | STAT3 (0.54) | STAT3HTTGSK3BCACNA1FPOLB | |
| SCHEMBL3868260 | 0.75 | GSK3B (0.42) | FOXO1STAT3HTTKDM4EALDH1A1 | |
| SCHEMBL8111738 | 0.74 | STAT3 (0.60) | STAT3HTTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10857506 | 0.74 | HPGD (0.44) | STAT3KDM4EALDH1A1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013182-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007106537-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2007-09-20 | — | — | WO | disclosed |