Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 5/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874603 | 0.89 | POLB (0.38) | FOXO1POLBPIM1STAT3HTR3A | |
| SCHEMBL15241559 | 0.82 | STAT3 (0.44) | POLBGSK3BSTAT3HTTKDM4E | |
| SCHEMBL1343207 | 0.80 | GSK3B (0.44) | POLBGSK3BSTAT3HTT | |
| SCHEMBL3870352 | 0.78 | FOXO1 (0.44) | FOXO1POLBGSK3BSTAT3HTR3A | |
| SCHEMBL2082130 | 0.77 | STAT3 (0.39) | POLBGSK3BSTAT3HTTALDH1A1 | |
| SCHEMBL2082129 | 0.77 | STAT3 (0.39) | POLBGSK3BSTAT3HTTALDH1A1 | |
| SCHEMBL3870889 | 0.76 | FOXO1 (0.40) | FOXO1POLBGSK3BSTAT3HTR3A | |
| SCHEMBL3820416 | 0.75 | TOP1 (0.44) | STAT3KDM4EALDH1A1TDP1 | |
| SCHEMBL3868260 | 0.73 | GSK3B (0.42) | FOXO1POLBGSK3BSTAT3HTT | |
| SCHEMBL6171434 | 0.72 | POLB (0.52) | POLBPIM1HTR3AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013182-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007106537-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2007-09-20 | — | — | WO | disclosed |