Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL1804105 | 0.93 | HSD17B10 (0.54) | HSD17B10GLAALDH1A1KDM4ETSHR | |
| Propionic Acid SCHEMBL25174383 | 0.91 | HSD17B10 (0.57) | HSD17B10GLAALDH1A1KDM4ETSHR | |
| Pivalate SCHEMBL1828636 | 0.87 | HSD17B10 (0.48) | HSD17B10GLAALDH1A1KDM4ETSHR | |
| Fluoride SCHEMBL11426086 | 0.87 | USP2 (0.46) | HSD17B10GLAALDH1A1KDM4ETSHR | |
| Glycine SCHEMBL28837088 | 0.87 | HSD17B10 (0.53) | HSD17B10GLAALDH1A1KDM4ETSHR | |
| SCHEMBL8135220 | 0.87 | — | — | |
| SCHEMBL3167 | 0.87 | — | — | |
| SCHEMBL474212 | 0.87 | — | — | |
| Fluoride SCHEMBL7750159 | 0.87 | — | — | |
| SCHEMBL28231022 | 0.87 | USP2 (0.46) | HSD17B10GLAALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538182-B2 | Polypeptide and protein derivatives and process for their preparation | AMYLIN PHARMACEUTICALS, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-20070037967-A1 | conjugated by bridging molecules to proteins or polypeptides, reporter groups or cytotoxic agents; cancer | AMYLIN PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| US-7129327-B2 | Polypeptide and protein derivatives and process for their preparation | AMYLIN PHARMACEUTICALS, INC. (US) | 2006-10-31 | — | — | US | disclosed |
| US-20040081660-A1 | Polypeptide and protein derivatives and process for their preparation | AMYLIN PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-6673347-B1 | CONJUGATED TO POLYMER VIA SCHIFF BASE, HYDRAZONE, OXIME, OR AZOMETHINE COMPOUND; DIAGNOSING TUMORS AND METASTASIS | GRYPHON THERAPEUTICS | 2004-01-06 | — | — | US | disclosed |
| EP-0243929-B1 | Polypeptide and protein derivatives and process for their preparation | OFFORD ROBIN EWART (CH) | 1995-09-27 | — | — | EP | disclosed |
| EP-0243929-A2 | Polypeptide and protein derivatives and process for their preparation | Offord, Robin Ewart (CH) | 1987-11-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037967-A1 | conjugated by bridging molecules to proteins or polypeptides, reporter groups or cytotoxic agents; cancer | HDGFL3, HCCS, HDGF | HSD17B10 2856/4885GLA 2130/4885ALDH1A1 3182/4885 |
| US-20040081660-A1 | Polypeptide and protein derivatives and process for their preparation | INSRR, GIPR, HM13 | HSD17B10 4653/4885GLA 3931/4885ALDH1A1 4808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.