INSRR — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL147331	0.91	2/20
SCHEMBL141930	0.90	2/20
SCHEMBL142206	0.85	2/20
SCHEMBL144842	0.80	2/20
SCHEMBL144192	0.75	2/20
SCHEMBL144525	0.71	2/20
SCHEMBL146263	0.71	2/20
SCHEMBL141676	0.69	2/20
SCHEMBL145500	0.69	2/20
SCHEMBL144281	0.68	2/20
SCHEMBL141372	0.68	2/20
SCHEMBL145902	0.67	2/20
SCHEMBL146743	0.67	2/20
SCHEMBL144785	0.67	2/20
SCHEMBL147096	0.63	2/20
SCHEMBL144209	0.62	2/20
SCHEMBL144321	0.61	2/20
SCHEMBL146728	0.61	2/20
SCHEMBL147975	0.60	2/20
SCHEMBL144930	0.60	2/20

Clinical trials — most relevant to INSRR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway	PHASE4	COMPLETED
Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer	PHASE4	WITHDRAWN
Genetic Variants Replication Study Associated With Dependence on Sulfonylurea in Participants With Type 2 Diabetes	PHASE4	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes	PHASE2	RECRUITING
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer	PHASE2	COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans	PHASE1	COMPLETED
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans	PHASE1	COMPLETED
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans	nan	UNKNOWN
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients	nan	UNKNOWN
Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation	nan	UNKNOWN
IRS Proteins and Trastuzumab Resistance	nan	COMPLETED
Markers and Mechanisms of Macrovascular Disease in IDDM	nan	COMPLETED
Impact of Comprehensive Intervention on the Cardiometabolic Risk in Children With Central Obesity (IGENOI)Obesity	nan	COMPLETED
Is There Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?	nan	UNKNOWN
Epigenetics of Muscle Insulin Resistance	nan	COMPLETED
AR, IGF-IR, IR and Peripheral Artery Disease	nan	UNKNOWN
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Brown Seaweed Extract on Glycemic Control and Body Weight	nan	COMPLETED
Genetic Study for Infantile Onset Diabetes Mellitus	nan	UNKNOWN
Emerging Role of NOTCH-related Long Non-coding RNA(s) as Biomarkers in Liquid Biopsy From Colorectal Cancer Patients	nan	COMPLETED
Diagnostic Value of MicroRNA 210 In Preeclampsia	nan	UNKNOWN
Role of LncRNA H19 in The Regulation of IGF-1R Expression	nan	COMPLETED
Effects of Fish Oils on Inflammation and Insulin Resistance	nan	COMPLETED
Pharmacogenetic Profiling of Antipsychotics-Induced X-Syndrome and Diabetes (PAXD)	nan	UNKNOWN
Epigenetics and the Origin of Muscle Insulin Resistance in Humans	nan	COMPLETED
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
The Role of TBC1D4 in Exercise- and Insulin-induced Glucose Metabolism in Human Skeletal Muscle	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a INSRR binder may also engage these)

Protein	Name	Similarity
Q64716	—	1.000	Q64716 →
Q9WTL4	—	1.000	Q9WTL4 →
P14617	—	1.000	P14617 →
Q8BYG9	—	0.990	Q8BYG9 →
Q5M936	—	0.989	Q5M936 →
Q92729	—	0.988	Q92729 →
INSR	Insulin receptor	0.987	landscape →
P35546	—	0.987	P35546 →
Q03145	—	0.987	Q03145 →
O73791	—	0.987	O73791 →
O94910	—	0.986	O94910 →
P0C0K6	—	0.986	P0C0K6 →
Q499S5	—	0.986	Q499S5 →
Q90830	—	0.986	Q90830 →
Q9Z2Y2	—	0.986	Q9Z2Y2 →
Q06805	—	0.985	Q06805 →
Q9DBX3	—	0.985	Q9DBX3 →
P0C0K7	—	0.985	P0C0K7 →
P41246	—	0.985	P41246 →
P15208	—	0.985	P15208 →
Q7TQN3	—	0.985	Q7TQN3 →
Q62190	—	0.985	Q62190 →
A1X150	—	0.984	A1X150 →
O73798	—	0.984	O73798 →
O97831	—	0.984	O97831 →
P98163	—	0.984	P98163 →
O09127	—	0.984	O09127 →
O43278	—	0.984	O43278 →
P0C5J5	—	0.984	P0C5J5 →
LOXL3	Lysyl oxidase homolog 3	0.984	landscape →