Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871902 | 0.88 | PIK3CA (0.37) | PIK3CAMKNK1MKNK2PIK3CDPIK3CG | |
| SCHEMBL3877554 | 0.86 | MKNK1 (0.39) | PIK3CAMKNK1MKNK2PIK3CDPIK3CG | |
| Hydrochloric Acid SCHEMBL3879058 | 0.81 | PIK3CA (0.44) | PIK3CAMKNK1MKNK2PIK3CDPIK3CG | |
| SCHEMBL3865934 | 0.80 | MKNK1 (0.40) | MKNK1MKNK2TGFBR1EIF4EFLT3 | |
| SCHEMBL3867609 | 0.76 | POLB (0.36) | PIK3CAMKNK1MKNK2 | |
| SCHEMBL3870713 | 0.76 | PIK3CA (0.45) | PIK3CAMKNK1MKNK2FLT3NEK2 | |
| SCHEMBL3873971 | 0.75 | GRM2 (0.35) | PIK3CAMKNK1MKNK2TGFBR1FLT3 | |
| SCHEMBL3850040 | 0.75 | FLT3 (0.45) | MKNK1MKNK2TGFBR1FLT3 | |
| SCHEMBL3877558 | 0.75 | MKNK1 (0.34) | MKNK1MKNK2EIF4E | |
| SCHEMBL3872041 | 0.74 | MKNK1 (0.36) | PIK3CAMKNK1MKNK2TGFBR1EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |