Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | EIF4E | P06730 | 3/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | NEK2 | P51955 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877558 | 0.88 | MKNK1 (0.34) | MKNK1MKNK2EIF4E | |
| SCHEMBL3871263 | 0.88 | PIK3CA (0.41) | PIK3CAMKNK1MKNK2PIK3CDPIK3CB | |
| SCHEMBL3865937 | 0.83 | MKNK1 (0.35) | MKNK1MKNK2EIF4E | |
| SCHEMBL3850042 | 0.80 | FLT3 (0.38) | MKNK1MKNK2FLT3KCNH2 | |
| SCHEMBL3867613 | 0.80 | POLB (0.32) | — | |
| SCHEMBL3846605 | 0.79 | TGFBR1 (0.37) | TGFBR1FLT3NEK2 | |
| SCHEMBL3873973 | 0.79 | GRM2 (0.32) | TGFBR1FLT3 | |
| SCHEMBL3846575 | 0.78 | MKNK1 (0.39) | PIK3CAMKNK1MKNK2EIF4ETGFBR1 | |
| SCHEMBL3872044 | 0.77 | MKNK1 (0.32) | MKNK1MKNK2EIF4E | |
| SCHEMBL3855941 | 0.77 | FLT3 (0.37) | MKNK1MKNK2TGFBR1FLT3NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |