Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.55 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.50 |
| ▸ | RHEB | Q15382 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.49 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.49 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.49 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.49 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.49 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3423810 | 0.94 | RHEB (0.52) | EGLN1PIN1RHEBGRIN2DGRIN3B | |
| SCHEMBL4309662 | 0.86 | EGLN1 (0.63) | EGLN1PIN1RHEBGRIN2DGRIN3B | |
| SCHEMBL3423120 | 0.86 | PIN1 (0.56) | EGLN1PIN1RHEBGRIN2DGRIN3B | |
| SCHEMBL1259840 | 0.83 | EGLN1 (0.46) | EGLN1GRIN2DGRIN3BLMNAGRIK1 | |
| SCHEMBL17092653 | 0.81 | EGLN1 (0.55) | EGLN1PIN1RHEBHRH4HRH3 | |
| SCHEMBL5191162 | 0.77 | EGLN1 (0.44) | EGLN1RHEBGRIN2DGRIN3BLMNA | |
| SCHEMBL6221832 | 0.77 | HRH4 (0.51) | EGLN1HRH4HRH3 | |
| SCHEMBL1193135 | 0.75 | MAPT (0.52) | EGLN1RHEBGRIN2DGRIN3BLMNA | |
| SCHEMBL523253 | 0.73 | RHEB (0.54) | PIN1RHEBLMNAMAPTHRH4 | |
| SCHEMBL2243706 | 0.73 | PIN1 (0.66) | EGLN1PIN1LMNAHRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010177-A2 | COMBINATION HISTAMINE H1R AND H4R ANTAGONIST THERAPY FOR TREATING PRURITUS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120690-A2 | COMBINATION HISTAMINE H1R AND H4R ANTAGONIST THERAPY FOR TREATING PRURITUS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-25 | — | — | WO | disclosed |