SCHEMBL523253

SCHEMBL523253

O=C(O)c1nc2cc(Cl)ccc2[nH]1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RHEB Q15382 2/20 0.54
PIN1 Q13526 2/20 0.53
F7 P08709 2/20 0.51
F3 P13726 2/20 0.51
MAPT P10636 4/20 0.47
KMT2A Q03164 3/20 0.47
HRH4 Q9H3N8 4/20 0.45
HRH3 Q9Y5N1 2/20 0.45
SMN1; SMN2 Q16637 4/20 0.44
NTSR1 P30989 2/20 0.44
MEN1 O00255 2/20 0.44
ALDH1A1 P00352 2/20 0.44
PKM P14618 1/20 0.44
HPGD P15428 1/20 0.44
NPY1R P25929 1/20 0.44
NPY2R P49146 1/20 0.44
KDR P35968 1/20 0.43
NPC1 O15118 3/20 0.43
LMNA P02545 3/20 0.43
NPSR1 Q6W5P4 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11229272 0.86 MAPT (0.47) RHEBF7F3MAPTKMT2A
SCHEMBL29527229 0.86 PIN1 (0.66) RHEBPIN1MAPTKMT2AHRH4
SCHEMBL523254 0.86 PIN1 (0.66) RHEBPIN1MAPTKMT2AHRH4
SCHEMBL27417845 0.85 HRH4 (0.47) RHEBF7F3MAPTKMT2A
SCHEMBL29414225 0.85 KMT2A (0.46) RHEBF7F3MAPTKMT2A
SCHEMBL3064168 0.85 KMT2A (0.46) RHEBF7F3MAPTKMT2A
SCHEMBL6017009 0.83 PIN1 (0.57) RHEBPIN1F7F3MAPT
SCHEMBL6016850 0.83 HRH4 (0.56) RHEBHRH4HRH3
SCHEMBL25812917 0.82 HRH4 (0.48) RHEBF7F3MAPTKMT2A
SCHEMBL24198762 0.81 HRH4 (0.44) RHEBF7F3MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12469929-B2 Separator, electrical apparatus containing such separator, and preparation method thereof CONTEMPORARY AMPEREX TECHNOLOGY (HONG KONG) LIMITED (CN) 2025-11-11 US claimed
EP-4397399-A2 MEMBRANES COMPRISING A LAYER OF METAL ORGANIC FRAMEWORK PARTICLES G2O Water Technologies Limited (GB) 2024-07-10 EP claimed
EP-3774001-A1 MEMBRANES COMPRISING A LAYER OF METAL ORGANIC FRAMEWORK PARTICLES G2O Water Technologies Limited (GB) 2021-02-17 EP claimed
US-20210016232-A1 MEMBRANES COMPRISING A LAYER OF METAL ORGANIC FRAMEWORK PARTICLES EVOVE LTD (GB) 2021-01-21 US claimed
WO-2012175823-A1 NOVEL HYBRID ORGANIC/INORGANIC IM-22 SOLID, AND USE THEREOF IN THE SEPARATION OF MULTI-BRANCHED PARAFFINS FROM LINEAR AND SINGLE-BRANCHED PARAFFINS IFP Energies Nouvelles (FR) 2012-12-27 WO claimed
EP-2167077-A2 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR Bayer Schering Pharma Aktiengesellschaft (DE) 2010-03-31 EP claimed
US-20090023741-A1 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR BAYER SCHERING PHARMA AG (DE) 2009-01-22 US claimed
WO-2008152099-A2 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-12-18 WO claimed
US-12629639-B2 Spacer for a spiral wound membrane EVOVE LTD (GB) 2026-05-19 US disclosed
US-20250346575-A1 ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-11-13 US disclosed
US-12234398-B2 Metal organic framework (MOF) glass composite comprising metal halide perovskite THE UNIVERSITY OF QUEENSLAND (AU) 2025-02-25 US disclosed
US-20240376377-A1 A METAL ORGANIC FRAMEWORK (MOF) GLASS COMPOSITE COMPRISING METAL HALIDE PEROVSKITE THE UNIVERSITY OF QUEENSLAND (AU) 2024-11-14 US disclosed
EP-4431505-A1 ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF Korea Research Institute of Chemical Technology (KR) 2024-09-18 EP disclosed
US-12060333-B2 Aminocarbamoyl compounds for the treatment of viral infections HOFFMANN-LA ROCHE INC. (US) 2024-08-13 US disclosed
EP-0832065-B1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER (US) 2001-10-10 EP disclosed
EP-1134213-A2 Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides PFIZER INC. (US) 2001-09-19 EP disclosed
US-6277877-B1 GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS PFIZER, INC. 2001-08-21 US disclosed
US-6107329-A HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS PFIZER, INC. (US) 2000-08-22 US disclosed
EP-0832065-A1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER INC. (US) 1998-04-01 EP disclosed
WO-1996039384-A1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER, INC. (US) 1996-12-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023741-A1 ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR PTGER2, PTGER1, PTGDR2 RHEB 3847/4885PIN1 2950/4885F7 4501/4885
US-12629639-B2 Spacer for a spiral wound membrane AQP1, AQP3, AQP4 RHEB 2718/4885PIN1 3096/4885F7 1067/4885
US-12060333-B2 Aminocarbamoyl compounds for the treatment of viral infections SARS1, BCAT1, SLC1A5 RHEB 104/4885PIN1 3647/4885F7 997/4885
US-20250346575-A1 ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF CRBN, IDH1, IDH2 RHEB 1047/4885PIN1 60/4885F7 4871/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.