Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13874265 | 0.83 | SRC (0.46) | MKNK1MKNK2MAP3K14 | |
| SCHEMBL3868735 | 0.83 | LMNA (0.40) | LMNAMKNK1MKNK2EIF2AK4MAP3K14 | |
| SCHEMBL3847902 | 0.81 | SLC2A1 (0.47) | MKNK1MKNK2MAP3K14NPC1 | |
| Hydrochloric Acid SCHEMBL3872804 | 0.80 | MKNK1 (0.41) | MKNK1MKNK2ICAM1EIF2AK4NPC1 | |
| SCHEMBL3865934 | 0.76 | MKNK1 (0.40) | MKNK1MKNK2NPC1RAB9AALDH1A1 | |
| SCHEMBL13874263 | 0.74 | MAP3K14 (0.45) | MKNK1MKNK2MAP3K14 | |
| SCHEMBL3870713 | 0.73 | PIK3CA (0.45) | MKNK1MKNK2EIF2AK4MAP3K14ALDH1A1 | |
| SCHEMBL5363103 | 0.68 | LMNA (0.52) | KDM4ELMNAL3MBTL1LTA4HNPC1 | |
| SCHEMBL4592012 | 0.66 | KDM4E (0.63) | SMYD3KDM4ELMNAMAPK1HIF1A | |
| SCHEMBL18291424 | 0.65 | KDM4E (0.54) | KDM4EICAM1LTA4HNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |