Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 3/20 | 0.36 |
| ▸ | SCN1A | P35498 | 2/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13841666 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2HTTL3MBTL1LMNANPSR1 | |
| SCHEMBL3242888 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2HTTL3MBTL1LMNANPSR1 | |
| SCHEMBL11893100 | 0.75 | PRKCA (0.42) | — | |
| SCHEMBL772511 | 0.74 | PRKCA (0.49) | L3MBTL1 | |
| SCHEMBL3242890 | 0.72 | MEN1 (0.42) | L3MBTL1MAPTLMNANPSR1MEN1 | |
| SCHEMBL772512 | 0.68 | ALDH1A1 (0.37) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL3871757 | 0.67 | KMT2A (0.37) | SMN1; SMN2RAB9ALMNANPSR1MEN1 | |
| SCHEMBL11864448 | 0.67 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTNPC1RAB9AL3MBTL1 | |
| SCHEMBL9396750 | 0.66 | MAPT (0.51) | SMN1; SMN2HTTNPC1RAB9AL3MBTL1 | |
| SCHEMBL14253440 | 0.66 | SCN9A (0.41) | SMN1; SMN2HTTL3MBTL1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099804-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | Brystol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| EP-2029606-A2 | CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2008089027-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2007140254-A2 | CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-06 | — | — | WO | disclosed |