Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833789 | 0.81 | CREBBP (0.45) | L3MBTL1SMN1; SMN2ALDH1A1MAPK1MAPT | |
| SCHEMBL15069765 | 0.80 | CREBBP (0.60) | SMN1; SMN2ALDH1A1MAPK1MAPTGAA | |
| SCHEMBL27985924 | 0.76 | NPC1 (0.47) | L3MBTL1ALDH1A1TP53HPGDMAPT | |
| Methane SCHEMBL27631694 | 0.76 | NPC1 (0.50) | ALDH1A1MAPTMEN1KMT2ACREBBP | |
| SCHEMBL8951215 | 0.74 | GLS (0.49) | SMN1; SMN2ALDH1A1TP53HPGDTSHR | |
| SCHEMBL30516913 | 0.73 | MAPT (0.45) | SMN1; SMN2ALDH1A1MAPTCREBBPGLS | |
| SCHEMBL3610098 | 0.73 | MAPT (0.45) | SMN1; SMN2ALDH1A1MAPTCREBBPGLS | |
| SCHEMBL27129636 | 0.70 | L3MBTL1 (0.67) | L3MBTL1SMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL427515 | 0.70 | GLS (0.55) | L3MBTL1ALDH1A1TSHRMAPTMEN1 | |
| SCHEMBL17678004 | 0.70 | GLS (0.48) | SMN1; SMN2ALDH1A1TSHRMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848694-B1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | HOFFMANN LA ROCHE (CH) | 2009-11-25 | — | — | EP | claimed |
| EP-1848694-B1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | HOFFMANN LA ROCHE (CH) | 2009-11-25 | — | — | EP | disclosed |