Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.80 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.79 |
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 7/20 | 0.71 |
| ▸ | MGLL | Q99685 | 1/20 | 0.67 |
| ▸ | MLYCD | O95822 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163396 | 0.91 | HSP90AA1 (0.68) | HSP90AA1HDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL9422525 | 0.90 | HSP90AA1 (0.91) | HSP90AA1HDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL17372667 | 0.88 | HSP90AA1 (0.77) | HSP90AA1HDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL6571020 | 0.88 | HDAC2 (1.00) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL751214 | 0.88 | HDAC2 (0.80) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL3642101 | 0.87 | HSP90AA1 (0.63) | HSP90AA1HDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL6841899 | 0.86 | HDAC2 (0.78) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL7282271 | 0.86 | HDAC2 (0.78) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL28193721 | 0.86 | HDAC2 (0.77) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL2919151 | 0.85 | HDAC2 (0.76) | HDAC2HDAC8HDAC6RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601868-B2 | Such as 4-(cyclopropylmethoxy)-N-(2-{4-[1-(1-pyrrolidinyl)ethyl]phenyl}ethyl)benzamide having melanin-concentrating hormone antagonistic action, for prophylaxis and/or treatment of obesity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-13 | — | — | US | disclosed |
| US-20060128690-A1 | Amine derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1593667-A1 | AMINE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2005-11-09 | — | — | EP | disclosed |
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128690-A1 | Amine derivative | MC1R, MC2R, MC4R | HSP90AA1 2143/4885HDAC2 581/4885HDAC8 1279/4885 |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | HSP90AA1 3068/4885HDAC2 674/4885HDAC8 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.