Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318792 | 0.89 | PTGS2 (0.37) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL3869145 | 0.85 | PTGS2 (0.53) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL3870142 | 0.84 | PTGS2 (0.52) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL3869939 | 0.83 | PTGS2 (0.51) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL27773589 | 0.81 | PTGS2 (0.53) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL3871928 | 0.74 | PTGS2 (0.65) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL4321256 | 0.73 | PTGS2 (0.40) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL3870953 | 0.73 | PTGS2 (0.40) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL3881581 | 0.73 | PTGS2 (0.47) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL3871405 | 0.73 | CXCL8 (0.39) | PTGS2ABCB11PTGS1PPARGNR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046723-A2 | PHENYLACETIC ACID DERIVATIVES AS COX-2 INHIBITORS | Novartis AG (CH) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008002853-A2 | PHENYLACETIC ACID DERIVATIVES AS COX-2 INHIBITORS | NOVARTIS AG (CH) | 2008-01-03 | — | — | WO | disclosed |