Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | F10 | P00742 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864134 | 0.82 | F10 (0.56) | KDRF10MAPT | |
| SCHEMBL3871851 | 0.78 | F10 (0.66) | KDRF10 | |
| SCHEMBL3864953 | 0.73 | F10 (0.64) | F10 | |
| SCHEMBL3862482 | 0.70 | DGAT1 (0.43) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL3864192 | 0.67 | F10 (0.69) | KDRF10TP53KDM4ENPC1 | |
| SCHEMBL4371202 | 0.67 | KDR (0.55) | KDRMEN1POLBKMT2AHIF1A | |
| SCHEMBL4367576 | 0.65 | METAP1 (0.49) | KDRMEN1KMT2AHIF1ATP53 | |
| SCHEMBL4372770 | 0.63 | KDR (0.55) | KDRMEN1POLBKMT2ATP53 | |
| SCHEMBL4367763 | 0.63 | KDR (0.55) | KDRMEN1KMT2AHIF1ATP53 | |
| SCHEMBL3866754 | 0.62 | F10 (0.89) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |