Ammonia Solution, Strong

SCHEMBL3875475

CCCCC1(CC)C(=O)SC2=C(C(=O)C(SCC(=O)N[C@@H](C(=O)NCCS(=O)(=O)O)c3ccc(O)cc3)C=C2)C(c2ccccc2)C1O.N

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Ammonia Solution, Strong SCHEMBL4622376	0.91	—	—
SCHEMBL5273747	0.86	—	—
Ammonia Solution, Strong SCHEMBL4637644	0.71	NR1H4 (0.33)	—
SCHEMBL6271127	0.68	SLC10A2 (0.35)	—
Ammonia Solution, Strong SCHEMBL1183723	0.68	SLC10A2 (0.52)	—
SCHEMBL3875478	0.68	MTTP (0.32)	—
SCHEMBL931590	0.68	SLC10A2 (0.36)	—
SCHEMBL5762558	0.68	SLC10A2 (0.53)	—
Ammonia Solution, Strong SCHEMBL3611677	0.66	SLC10A2 (0.49)	—
SCHEMBL3611683	0.65	SLC10A2 (0.34)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2013165-A1	DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSOR TION INHIBITOR ACTIVIT.	Astra Zeneca AB (SE)	2009-01-14	—	—	EP	disclosed
WO-2007126358-A1	DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSOR TION INHIBITOR ACTIVIT.	ASTRAZENECA AB (SE)	2007-11-08	—	—	WO	disclosed
EP-1699758-A1	DIPHENYLAZETIDINONE DERIVATES PROCESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY	AstraZeneca AB (SE)	2006-09-13	—	—	EP	disclosed
WO-2005061451-A1	DIPHENYLAZETIDINONE DERIVATES PROCESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY	ASTRAZENECA AB (SE)	2005-07-07	—	—	WO	disclosed