Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | SDHB | P21912 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286312 | 0.83 | IDO1 (0.52) | MEN1KMT2ALMNAHTTTSHR | |
| SCHEMBL4051446 | 0.77 | CYP1A2 (0.48) | ALDH1A1CYP2C19DAGLBCA12CA1 | |
| SCHEMBL19845815 | 0.76 | CA2 (0.52) | KMT2AALDH1A1KDM4ELMNADAGLB | |
| SCHEMBL249386 | 0.76 | CA2 (0.63) | HPGDALDH1A1POLBRAB9ATSHR | |
| Benzene SCHEMBL27447210 | 0.76 | CA2 (0.63) | HPGDALDH1A1POLBRAB9ATSHR | |
| SCHEMBL23184057 | 0.75 | MEN1 (0.59) | MEN1KMT2ANTSR1HPGDMAPT | |
| SCHEMBL18388725 | 0.75 | MEN1 (0.59) | MEN1KMT2ANTSR1HPGDMAPT | |
| SCHEMBL4952656 | 0.74 | CA2 (0.58) | KMT2AHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL17367827 | 0.74 | MEN1 (0.79) | MEN1KMT2ANTSR1HPGDMAPT | |
| SCHEMBL17970040 | 0.74 | MEN1 (0.79) | MEN1KMT2ANTSR1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498356-B2 | Substituted amino carboxylic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2009-03-03 | — | — | US | disclosed |
| US-7498356-B2 | Substituted amino carboxylic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2009-03-03 | — | — | US | disclosed |
| US-7498356-B2 | Substituted amino carboxylic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2009-03-03 | — | — | US | disclosed |
| US-7358248-B2 | Substituted amino carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2008-04-15 | — | — | US | disclosed |
| US-7358248-B2 | Substituted amino carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2008-04-15 | — | — | US | disclosed |
| US-7358248-B2 | Substituted amino carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2008-04-15 | — | — | US | disclosed |
| EP-1814869-A2 | SUBSTITUTED AMINO ACIDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20060122223-A1 | Substituted amino carboxylic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-06-08 | — | — | US | disclosed |
| WO-2006055725-A2 | SUBSTITUTED AMINO ACIDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-26 | — | — | WO | disclosed |
| EP-1622886-A2 | SUBSTITUTED AMINO CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-08 | — | — | EP | disclosed |
| US-20040266789-A1 | Substituted amino carboxylic acids | INSTITUTE FOR DIABETES DISCOVERY, L.L.C. | 2004-12-30 | — | — | US | disclosed |
| WO-2004099171-A2 | SUBSTITUTED AMINO CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122223-A1 | Substituted amino carboxylic acids | PTPRS, PTPRO, PTPRJ | MEN1 3043/4885KMT2A 2273/4885NTSR1 1638/4885 |
| US-20040266789-A1 | Substituted amino carboxylic acids | PTPRS, PPM1B, PTPRO | MEN1 2140/4885KMT2A 2369/4885NTSR1 1536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.