Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.71 |
| ▸ | LMNA | P02545 | 7/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 6/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 7/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.67 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28756963 | 0.91 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL11697622 | 0.83 | NPSR1 (1.00) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL11149053 | 0.83 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL5455050 | 0.83 | SMN1; SMN2 (0.88) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL23453329 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL23453374 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL23457320 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL5447885 | 0.81 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL31310486 | 0.80 | ALDH1A1 (1.00) | SMN1; SMN2LMNANPSR1HTTRAB9A | |
| SCHEMBL9425942 | 0.80 | ALDH1A1 (0.60) | SMN1; SMN2LMNANPSR1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560591-B2 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2009-07-14 | — | — | US | disclosed |
| US-20080207764-A1 | Novel Benzamidine Derivatives Having Anti-Inflammatory and Immunosuppressive Activity | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2008-08-28 | — | — | US | disclosed |
| EP-1363875-B1 | NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY | ROTTAPHARM SPA (IT) | 2008-08-06 | — | — | EP | disclosed |
| US-20070135523-A1 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity | ROTTA RESEARCH LABORATORIUM S.P.A | 2007-06-14 | — | — | US | disclosed |
| US-7202277-B2 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2007-04-10 | — | — | US | disclosed |
| US-20040110801-A1 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive | ROTTAPHARM BIOTECH S.R.L. (IT) | 2004-06-10 | — | — | US | disclosed |
| EP-1363875-A2 | NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002070468-A2 | NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135523-A1 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive activity | HRH4, HRH3, HRH2 | SMN1; SMN2 4509/4885LMNA 4562/4885NPSR1 2187/4885 |
| US-20080207764-A1 | Novel Benzamidine Derivatives Having Anti-Inflammatory and Immunosuppressive Activity | HRH4, HRH3, HRH2 | SMN1; SMN2 4500/4885LMNA 4621/4885NPSR1 2213/4885 |
| US-20040110801-A1 | Novel benzamidine derivatives having anti-inflammatory and immunosuppressive | HRH4, NAT1, HRH3 | SMN1; SMN2 4559/4885LMNA 4423/4885NPSR1 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.