Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 7/20 | 0.50 |
| ▸ | RBP4 | P02753 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | GALR2 | O43603 | 4/20 | 0.45 |
| ▸ | GALR1 | P47211 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14614071 | 0.93 | MALT1 (0.49) | MALT1RBP4TRPV1GALR2GALR1 | |
| SCHEMBL3884310 | 0.91 | TRPV1 (0.48) | MALT1RBP4TRPV1GALR2GALR1 | |
| SCHEMBL3876780 | 0.88 | GALR2 (0.46) | MALT1RBP4TRPV1GALR2GALR1 | |
| SCHEMBL3881361 | 0.88 | TRPV1 (0.47) | MALT1RBP4TRPV1GALR2GALR1 | |
| SCHEMBL3889542 | 0.88 | MALT1 (0.45) | MALT1RBP4TRPV1GALR2GALR1 | |
| SCHEMBL3880207 | 0.87 | GALR2 (0.51) | TRPV1GALR2GALR1 | |
| SCHEMBL3888771 | 0.86 | HSD11B1 (0.46) | GALR2GALR1 | |
| SCHEMBL3879411 | 0.86 | TRPA1 (0.47) | RBP4TRPV1GALR2GALR1GAA | |
| SCHEMBL3879455 | 0.86 | GALR2 (0.46) | TRPV1GALR2GALR1 | |
| SCHEMBL3881028 | 0.85 | GALR2 (0.44) | TRPV1GALR2GALR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |