Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.38 |
| ▸ | KAT7 | O95251 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592088 | 0.90 | REN (0.41) | REN | |
| SCHEMBL5616691 | 0.88 | REN (0.39) | REN | |
| SCHEMBL3878835 | 0.84 | REN (0.44) | REN | |
| SCHEMBL3881875 | 0.84 | REN (0.44) | REN | |
| SCHEMBL4217493 | 0.84 | REN (0.38) | RENKAT6AKAT5KAT7GPR119 | |
| SCHEMBL3881718 | 0.83 | REN (0.48) | RENKAT6AKAT5KAT7EPHA2 | |
| SCHEMBL5592100 | 0.81 | REN (0.35) | REN | |
| SCHEMBL12991819 | 0.80 | REN (0.47) | RENKAT6AKAT5KAT7GPR119 | |
| SCHEMBL3569485 | 0.80 | REN (0.47) | RENKAT6AKAT5KAT7GPR119 | |
| SCHEMBL3569483 | 0.80 | REN (0.47) | RENKAT6AKAT5KAT7GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010488-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117559-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |