Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3881875 | 1.00 | REN (0.44) | RENGRIN2BGRM5 | |
| SCHEMBL5592088 | 0.87 | REN (0.41) | RENGRIN2BGRM5 | |
| SCHEMBL3877929 | 0.84 | REN (0.40) | REN | |
| SCHEMBL5616691 | 0.83 | REN (0.39) | RENGRIN2B | |
| SCHEMBL4295733 | 0.81 | REN (0.52) | RENGRIN2B | |
| SCHEMBL4292326 | 0.81 | REN (0.52) | RENGRIN2B | |
| SCHEMBL4295728 | 0.81 | REN (0.52) | RENGRIN2B | |
| SCHEMBL4292328 | 0.81 | REN (0.52) | RENGRIN2B | |
| SCHEMBL4302202 | 0.81 | REN (0.52) | RENGRIN2B | |
| SCHEMBL5592100 | 0.81 | REN (0.35) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010488-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117559-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |