Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 8/20 | 0.43 |
| ▸ | ACACA | Q13085 | 6/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879034 | 0.92 | CYP1A2 (0.51) | PIK3CAHSD17B10L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL3880628 | 0.91 | TRPV1 (0.44) | ACACBACACAPIK3CAHSD17B10L3MBTL1 | |
| SCHEMBL3877310 | 0.90 | PIK3CA (0.42) | ACACBPIK3CAHSD17B10L3MBTL1CYP1A2 | |
| SCHEMBL3882030 | 0.89 | CYP1A2 (0.47) | ACACBACACAPIK3CAHSD17B10L3MBTL1 | |
| SCHEMBL3876620 | 0.89 | CYP1A2 (0.47) | ACACBPIK3CAHSD17B10L3MBTL1CYP1A2 | |
| SCHEMBL3878058 | 0.89 | PIK3CA (0.43) | ACACBACACAPIK3CATRPV1PIK3CB | |
| SCHEMBL3883895 | 0.87 | PIK3CA (0.45) | PIK3CAHSD17B10TSHRKDM4EALDH1A1 | |
| SCHEMBL3884732 | 0.86 | TRPV1 (0.42) | PIK3CAHSD17B10L3MBTL1TSHRKDM4E | |
| SCHEMBL3879904 | 0.86 | TRPV1 (0.43) | PIK3CAL3MBTL1KDM4EGAAHPGD | |
| SCHEMBL3888123 | 0.85 | PIK3CA (0.43) | PIK3CAHSD17B10L3MBTL1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | GPR174, GPR68, PPARG | ACACB 2782/4885ACACA 3259/4885PIK3CA 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.