Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3462829 | 0.92 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL3460543 | 0.82 | MAPK1 (0.43) | CHRM3MAPK1 | |
| SCHEMBL3462783 | 0.82 | MAPK1 (0.43) | MAPK1ACP1 | |
| SCHEMBL3462636 | 0.82 | NTRK1 (0.44) | NTRK1CCNT1MAPK1 | |
| SCHEMBL3461567 | 0.80 | MAPK1 (0.50) | MAPK1 | |
| SCHEMBL3461568 | 0.80 | NTRK1 (0.40) | NTRK1MAPK1 | |
| SCHEMBL3461957 | 0.79 | WDR5 (0.42) | NTRK1NTRK3NTRK2CDK2MAPK1 | |
| SCHEMBL3462191 | 0.79 | MAPK1 (0.45) | CHRM3MAPK1 | |
| SCHEMBL3461186 | 0.79 | NTRK1 (0.43) | NTRK1NTRK3NTRK2MAPK1 | |
| SCHEMBL3466872 | 0.78 | MAPK1 (0.41) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |