Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL237494 | 0.77 | HTR2C (0.38) | BACE1HRH3PPARGPPARDPPARA | |
| SCHEMBL3879268 | 0.74 | BACE1 (0.35) | FFAR1RENCTSDBACE1BACE2 | |
| SCHEMBL612858 | 0.73 | NPC1 (0.38) | FFAR1CTSKPTGESACACB | |
| SCHEMBL612960 | 0.73 | TAAR1 (0.39) | FFAR1RENCTSDBACE1BACE2 | |
| SCHEMBL612036 | 0.72 | SIGMAR1 (0.43) | PTGES | |
| SCHEMBL613578 | 0.69 | HRH3 (0.39) | FFAR1RENCTSDBACE1BACE2 | |
| SCHEMBL236186 | 0.67 | FFAR1 (0.39) | FFAR1CYP2D6PTGESPPARGPPARD | |
| SCHEMBL237488 | 0.67 | TAAR1 (0.38) | FFAR1HRH3CYP2D6 | |
| SCHEMBL4178362 | 0.67 | LMNA (0.47) | FFAR1HRH3 | |
| SCHEMBL611605 | 0.67 | FFAR1 (0.35) | FFAR1HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |