Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.50 |
| ▸ | GALR2 | O43603 | 3/20 | 0.46 |
| ▸ | GALR1 | P47211 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | MST1 | P26927 | 1/20 | 0.44 |
| ▸ | STK4 | Q13043 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877122 | 1.00 | PDE4D (0.53) | PDE4DPIK3CAGALR2GALR1PIK3CG | |
| SCHEMBL3877917 | 0.88 | PIK3CA (0.53) | PIK3CAGALR2GALR1PIK3CGPIK3R1 | |
| SCHEMBL3881754 | 0.88 | PIK3CA (0.53) | PIK3CAGALR2GALR1PIK3CGPIK3R1 | |
| SCHEMBL3880818 | 0.88 | PIK3CA (0.53) | PIK3CAGALR2GALR1PIK3CGPIK3R1 | |
| SCHEMBL3883415 | 0.88 | PIK3CA (0.53) | PIK3CAGALR2GALR1PIK3CGPIK3R1 | |
| SCHEMBL3877376 | 0.88 | PIK3CA (0.52) | PDE4DPIK3CAPIK3CGMTORHSD11B1 | |
| SCHEMBL3877892 | 0.87 | NPSR1 (0.58) | PIK3CAGALR2GALR1PIK3CGPIK3R1 | |
| SCHEMBL3881496 | 0.87 | NPSR1 (0.58) | PIK3CAGALR2GALR1PIK3CGPIK3R1 | |
| SCHEMBL3891305 | 0.87 | GALR2 (0.53) | PIK3CAGALR2GALR1PIK3CGPIK3R1 | |
| SCHEMBL3880843 | 0.87 | PIK3CA (0.53) | PIK3CAGALR2GALR1PIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | GPR174, GPR68, PPARG | PDE4D 695/4885PIK3CA 1107/4885GALR2 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.