Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 6/20 | 0.59 |
| ▸ | ESR1 | P03372 | 3/20 | 0.59 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20764262 | 0.78 | ESRRG (0.78) | ESRRGESR1IKBKBRAB9ANPC1 | |
| SCHEMBL8502506 | 0.75 | IKBKB (0.65) | ESRRGESR1IKBKBMAPKAPK2ESR2 | |
| SCHEMBL20764016 | 0.74 | ESRRG (1.00) | ESRRGESR1MAPKAPK2ESR2RAB9A | |
| SCHEMBL20764080 | 0.73 | ESRRG (0.78) | ESRRGESR1MAPKAPK2ESR2CNR1 | |
| SCHEMBL1144473 | 0.73 | IKBKB (0.71) | ESRRGESR1IKBKBCNR1RAB9A | |
| SCHEMBL5983409 | 0.73 | IKBKB (0.71) | ESRRGESR1IKBKBMAPKAPK2ESR2 | |
| SCHEMBL6378947 | 0.72 | IKBKB (1.00) | ESRRGESR1IKBKBMAPKAPK2ESR2 | |
| SCHEMBL4929313 | 0.71 | AKT3 (0.62) | CNR1RAB9ANPC1HDAC1ACKR3 | |
| SCHEMBL27677406 | 0.71 | IKBKB (0.63) | ESRRGESR1IKBKBCNR1RAB9A | |
| SCHEMBL4930772 | 0.70 | ESRRG (0.73) | ESRRGESR1MAPKAPK2ESR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101764-B2 | MCH receptor antagonists | ELI LILLY AND COMPANY (US) | 2012-01-24 | — | — | US | disclosed |