Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | KHK | P50053 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3881624 | 1.00 | SYK (0.41) | SYKMAP3K12MAPK1HSD17B10SMO | |
| SCHEMBL13761561 | 1.00 | SYK (0.41) | SYKMAP3K12MAPK1HSD17B10SMO | |
| SCHEMBL3888291 | 0.92 | MAP3K12 (0.38) | SYKMAP3K12KHKPDPK1TGFBR1 | |
| SCHEMBL3882736 | 0.92 | MAP3K12 (0.38) | SYKMAP3K12KHKPDPK1TGFBR1 | |
| SCHEMBL3890901 | 0.92 | MAP3K12 (0.38) | SYKMAP3K12KHKPDPK1TGFBR1 | |
| SCHEMBL3883516 | 0.92 | MAP3K12 (0.38) | SYKMAP3K12KHKPDPK1TGFBR1 | |
| SCHEMBL13761505 | 0.92 | MAP3K12 (0.38) | SYKMAP3K12KHKPDPK1TGFBR1 | |
| SCHEMBL3877264 | 0.92 | MAP3K12 (0.38) | SYKMAP3K12KHKPDPK1TGFBR1 | |
| SCHEMBL13761580 | 0.91 | MAP3K12 (0.37) | MAP3K12KHKPDPK1TGFBR1AURKB | |
| SCHEMBL13761550 | 0.91 | MALT1 (0.39) | SYKMAP3K12KHKPDPK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | GPR174, GPR68, PPARG | SYK 2406/4885MAP3K12 2603/4885MAPK1 3202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.