Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220038 | 0.84 | PLAU (0.52) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL218188 | 0.82 | PLG (0.49) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL3891015 | 0.75 | OPRM1 (0.52) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL219690 | 0.73 | HDAC6 (0.60) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| SCHEMBL4966876 | 0.72 | ALDH1A1 (0.44) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL4965646 | 0.70 | OPRM1 (0.41) | HDAC1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL220311 | 0.70 | PLAU (0.52) | HDAC6HDAC8HDAC11HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL4965277 | 0.69 | OPRM1 (0.41) | HDAC1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL28562747 | 0.69 | HDAC6 (0.64) | HDAC6HDAC8HDAC11THRATHRB | |
| SCHEMBL30185502 | 0.69 | HDAC6 (0.64) | HDAC6HDAC8HDAC11THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751103-B1 | 4-(5-(AMINOMETHYL)-INDOLE-1-YLMETHYL)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | LILLY CO ELI (US) | 2009-01-14 | — | — | EP | claimed |