Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.34 |
| ▸ | GHSR | Q92847 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2066752 | 0.71 | CHKA (0.39) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL3607639 | 0.71 | CHKA (0.43) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL5658207 | 0.71 | — | — | |
| SCHEMBL3722313 | 0.70 | ADRA2C (0.40) | — | |
| SCHEMBL3540906 | 0.70 | CHRNB4 (0.44) | TGFBR1ACVR1KCNH2CHRNB4CHRNA3 | |
| SCHEMBL3540904 | 0.70 | CHRNB4 (0.44) | TGFBR1ACVR1KCNH2CHRNB4CHRNA3 | |
| SCHEMBL4162890 | 0.69 | CHKA (0.42) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL5659840 | 0.69 | CHKA (0.42) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL5656747 | 0.69 | CHKA (0.42) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL23561115 | 0.68 | TGFBR1 (0.39) | TGFBR1ACVR1KCNH2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013178-A1 | PIPERAZINE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUE (GHS) RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007113202-A1 | PIPERAZINE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUE (GHS) RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | WO | disclosed |