Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL538883 | 1.00 | — | — | |
| SCHEMBL16859 | 0.89 | — | — | |
| SCHEMBL5483305 | 0.89 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL6995610 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL11329859 | 0.80 | — | — | |
| Methane SCHEMBL16428422 | 0.80 | — | — | |
| SCHEMBL538884 | 0.80 | — | — | |
| Bromide SCHEMBL3220866 | 0.68 | — | — | |
| Carbon Tetrachloride SCHEMBL9012663 | 0.68 | TSHR (0.57) | ALDH1A1 | |
| SCHEMBL159721 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013180-A1 | NOVEL HETEROARYL-SUBSTITUTED ARYLAMINOPYRIDINE DERIVATIVES AS MEK INHIBITORS | Laboratoires Serono SA (CH) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007123936-A1 | NOVEL HETEROARYL-SUBSTITUTED ARYLAMINOPYRIDINE DERIVATIVES AS MEK INHIBITORS | LABORATOIRES SERONO SA (CH) | 2007-11-01 | — | — | WO | disclosed |