Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.84 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.84 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.53 |
| ▸ | CHRNG | P07510 | 1/20 | 0.53 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.53 |
| ▸ | CHRND | Q07001 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877873 | 1.00 | CHRNB2 (0.84) | CHRNB2CHRNA6CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL13354153 | 0.96 | CHRNB2 (0.78) | CHRNB2CHRNA6CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL13566551 | 0.91 | CHRNB2 (1.00) | CHRNB2CHRNA6CHRNA4 | |
| SCHEMBL13354150 | 0.88 | CHRNB2 (0.93) | CHRNB2CHRNA6CHRNA4 | |
| SCHEMBL14311699 | 0.87 | CHRNB4 (0.64) | CHRNB2CHRNA6CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL15483390 | 0.85 | CHRNB4 (0.64) | CHRNB2CHRNA6CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6585642 | 0.83 | AKT1 (0.66) | CHRNB2CHRNA6CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7409844 | 0.82 | CHRNB4 (0.67) | CHRNB2CHRNB4CHRNA3CHRNA4AKT1 | |
| SCHEMBL14030031 | 0.82 | CHRNB4 (0.67) | CHRNB2CHRNB4CHRNA3CHRNA4AKT1 | |
| Hydrochloric Acid SCHEMBL6585067 | 0.82 | AKT1 (0.65) | CHRNB2CHRNA6CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029557-B2 | Labeled A4B2 ligands and methods therefor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-05-12 | — | — | US | disclosed |
| US-20140050663-A1 | Labeled A4B2 Ligands and Methods Therefor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-20 | — | — | US | disclosed |
| US-8378109-B2 | Labeled ALPHA4BETA2 ligands and methods therefor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-02-19 | — | — | US | disclosed |
| US-20090297443-A1 | Labeled ALPHA4BETA2 Ligands and Methods Therefor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-12-03 | — | — | US | disclosed |
| WO-2006086068-A1 | LABELED ALPHA-4-BETA-2 LIGANDS AND METHODS THEREFOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140050663-A1 | Labeled A4B2 Ligands and Methods Therefor | CHRNB1, CHRNB4, CHRNB2 | CHRNB2 3/4885CHRNA6 22/4885CHRNB4 2/4885 |
| US-20090297443-A1 | Labeled ALPHA4BETA2 Ligands and Methods Therefor | CHRNE, CHRNB1, CHRNB4 | CHRNB2 4/4885CHRNA6 16/4885CHRNB4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.