Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | CTSG | P08311 | 1/20 | 0.52 |
| ▸ | CMA1 | P23946 | 1/20 | 0.52 |
| ▸ | CTRC | Q99895 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236740 | 0.87 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1MT-CO2ALOX5 | |
| SCHEMBL13783795 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1MT-CO2ALOX5 | |
| SCHEMBL12372537 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1MT-CO2ALOX5 | |
| SCHEMBL1023519 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1MT-CO2ALOX5 | |
| SCHEMBL17356841 | 0.81 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1ADORA2AMT-CO2 | |
| SCHEMBL3242391 | 0.80 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1MT-CO2ALOX5 | |
| SCHEMBL3242390 | 0.80 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1MT-CO2ALOX5 | |
| SCHEMBL8147581 | 0.80 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1MT-CO2ALOX5 | |
| SCHEMBL7829113 | 0.80 | ALDH1A1 (0.93) | ALDH1A1KMT2AMEN1MT-CO2ALOX5 | |
| SCHEMBL6747736 | 0.80 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550500-B2 | Bicyclic and tricyclic amines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-23 | — | — | US | disclosed |
| US-20060014964-A1 | Bicyclic and tricyclic amines as modulators of chemokine receptor activity | DUNCIA JOHN V | 2006-01-19 | — | — | US | disclosed |
| US-6960666-B2 | Bicyclic and tricyclic amines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-11-01 | — | — | US | disclosed |
| US-20040209876-A1 | Bicyclic and tricyclic amines as modulators of chemokine receptor activity | DUNCIA JOHN V (US) | 2004-10-21 | — | — | US | disclosed |
| US-6784200-B2 | SUCH AS N-3-(CIS-2,3,3A,4,9,9A-HEXAHYDRO-1H-BENZ(F)ISOINDOL-2-YL)-N-PROP-1-YL-N'-3 -ACETYLPHENYLUREA FOR PREVENTION OF INFLAMMATORY DISEASES (ASTHMA AND ALLERGIES) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-31 | — | — | US | disclosed |
| US-20040006084-A1 | Bicyclic and tricyclic amines as modulators of chemokine receptor activity | DUNCIA JOHN V (US) | 2004-01-08 | — | — | US | disclosed |
| US-6586446-B1 | Chemotaxic cytokine agonists or antagonists such as N(3-acetylphlenyl)-N'-(-2-((-3-((4-fluorophenyl)methyl)-8 -azabicyclo(3.2.1)oct-8-yl)methyl)-(2R)-1-cyclohexyl)urea, used as antiinflammatory agents for asthma or allergies | BRISTOL-MYERS SQUIBB COMPANY | 2003-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209876-A1 | Bicyclic and tricyclic amines as modulators of chemokine receptor activity | CCR1, CCR3, CCR10 | ALDH1A1 964/4885KMT2A 4001/4885MEN1 4366/4885 |
| US-20040006084-A1 | Bicyclic and tricyclic amines as modulators of chemokine receptor activity | CCR1, CCR3, CCR10 | ALDH1A1 964/4885KMT2A 4001/4885MEN1 4366/4885 |
| US-20060014964-A1 | Bicyclic and tricyclic amines as modulators of chemokine receptor activity | CCR3, CCR1, NR1I3 | ALDH1A1 1875/4885KMT2A 2520/4885MEN1 4734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.