Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.34 |
| ▸ | GRM5 | P41594 | 8/20 | 0.34 |
| ▸ | UBE2M | P61081 | 5/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3883227 | 0.94 | GRM5 (0.33) | L3MBTL3L3MBTL1GRM5ALDH1A1KDM4E | |
| SCHEMBL3880598 | 0.89 | GRM5 (0.37) | L3MBTL3L3MBTL1GRM5ALDH1A1 | |
| SCHEMBL3878666 | 0.86 | ACACB (0.35) | L3MBTL3L3MBTL1GRM5POLBHSD17B10 | |
| SCHEMBL3882073 | 0.85 | HRH3 (0.45) | L3MBTL3L3MBTL1GRM5TP53POLB | |
| SCHEMBL3878786 | 0.84 | ALDH1A1 (0.37) | L3MBTL1GRM5LMNATP53ALDH1A1 | |
| SCHEMBL3879089 | 0.83 | KDM4E (0.51) | L3MBTL3L3MBTL1UBE2MDCUN1D1LMNA | |
| SCHEMBL3879929 | 0.83 | HRH3 (0.41) | HTTKDM4E | |
| SCHEMBL3879360 | 0.82 | UBE2M (0.55) | L3MBTL3L3MBTL1UBE2MDCUN1D1LMNA | |
| SCHEMBL3880575 | 0.82 | HRH3 (0.50) | L3MBTL3L3MBTL1UBE2MDCUN1D1LMNA | |
| SCHEMBL3891896 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | claimed |