Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | CPA1 | P15085 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4166454 | 0.77 | CYP2D6 (0.30) | CYP2D6CYP2C19 | |
| SCHEMBL26097761 | 0.77 | CYP2D6 (0.30) | CYP2D6CYP2C19 | |
| SCHEMBL4172764 | 0.75 | CA1 (0.45) | CYP2D6CYP2C19 | |
| SCHEMBL6957514 | 0.73 | — | — | |
| SCHEMBL17275451 | 0.70 | CYP2D6 (0.31) | CYP2D6CYP2C19 | |
| SCHEMBL22781615 | 0.68 | EPHX1 (0.38) | — | |
| SCHEMBL31036601 | 0.67 | CYP2D6 (0.37) | MMEACECPA1ACE2CYP2D6 | |
| SCHEMBL7088563 | 0.66 | METAP2 (0.47) | — | |
| SCHEMBL73409 | 0.65 | — | — | |
| SCHEMBL1152458 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013184-A1 | SULFONAMIDE COMPOUNDS USEFUL AS EDG RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007129019-A1 | SULFONAMIDE COMPOUNDS USEFUL AS EDG RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |