Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884741 | 0.85 | KMT2A (0.43) | POLBKMT2AMEN1MAPTATM | |
| SCHEMBL3886789 | 0.76 | AKR1B1 (0.53) | POLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3883627 | 0.72 | CCR3 (0.42) | POLBKMT2AMEN1L3MBTL1SMN1; SMN2 | |
| SCHEMBL3816127 | 0.71 | RAB9A (0.44) | POLBMAPTRAB9AHPGDNPC1 | |
| SCHEMBL4140217 | 0.71 | GRM5 (0.44) | POLBKMT2AMEN1MAPTGRM5 | |
| SCHEMBL31038285 | 0.71 | TAAR1 (0.56) | POLBL3MBTL1RAB9AGAATSHR | |
| SCHEMBL11149531 | 0.70 | POLB (0.54) | POLBKMT2AMEN1MAPTATM | |
| SCHEMBL11149529 | 0.70 | POLB (0.54) | POLBKMT2AMEN1MAPTATM | |
| SCHEMBL4830376 | 0.69 | GRM5 (0.71) | POLBKMT2AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL9124424 | 0.69 | L3MBTL1 (0.46) | POLBKMT2AMEN1MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013197-A1 | PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007102771-A1 | PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-09-13 | — | — | WO | disclosed |