Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 7/20 | 0.54 |
| ▸ | PFKFB4 | Q16877 | 7/20 | 0.54 |
| ▸ | CMA1 | P23946 | 6/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3873533 | 0.89 | PFKFB4 (0.60) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL3886517 | 0.85 | PFKFB3 (0.53) | PFKFB3PFKFB4CMA1CYP2C9CYP2C19 | |
| SCHEMBL3879413 | 0.84 | PFKFB3 (0.63) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL3874658 | 0.80 | ROCK2 (0.47) | CYP2C9NPC1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3876651 | 0.78 | PFKFB4 (0.72) | PFKFB3PFKFB4CMA1 | |
| SCHEMBL3874981 | 0.76 | PFKFB4 (0.51) | PFKFB3PFKFB4CMA1NPC1RAB9A | |
| SCHEMBL3880933 | 0.76 | CYP2C9 (0.47) | CYP2C9RAB9AMEN1MAPTKMT2A | |
| SCHEMBL3874308 | 0.76 | PFKFB4 (0.45) | PFKFB3PFKFB4CMA1RORCCA1 | |
| SCHEMBL3886211 | 0.73 | PFKFB4 (0.64) | PFKFB3PFKFB4CMA1RAB9A | |
| SCHEMBL3881241 | 0.73 | LSS (0.43) | PFKFB3PFKFB4CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814846-B1 | 11BETA-HSD1 INHIBITORS | EVOTEC AG (DE) | 2009-04-08 | — | — | EP | disclosed |
| EP-1814846-A1 | 11BETA-HSD1 INHIBITORS | Evotec AG (DE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006048330-A1 | 11ΒΕΤΑ-HSD1 INHIBITORS | EVOTEC AG (DE) | 2006-05-11 | — | — | WO | disclosed |