Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.63 |
| ▸ | ITGB3 | P05106 | 19/20 | 0.63 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.41 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.40 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045472 | 0.90 | ITGAV (0.79) | ITGAVITGB3ITGA2BITGB6ITGB1 | |
| SCHEMBL4047951 | 0.86 | ITGAV (0.68) | ITGAVITGB3ITGA2BITGB6ITGB1 | |
| SCHEMBL7556616 | 0.84 | ITGAV (0.57) | ITGAVITGB3ITGA2BITGB6ITGB1 | |
| SCHEMBL4371634 | 0.84 | ITGAV (0.59) | ITGAVITGB3ITGB6ITGB8 | |
| SCHEMBL3886608 | 0.83 | ITGAV (0.57) | ITGAVITGB3ITGA2BITGB6ITGB1 | |
| SCHEMBL4045463 | 0.80 | ITGB3 (0.50) | ITGAVITGB3ITGA2BITGB5 | |
| SCHEMBL7945748 | 0.79 | ITGAV (0.77) | ITGAVITGB3ITGA2BITGB6ITGB1 | |
| SCHEMBL7945753 | 0.79 | ITGAV (0.77) | ITGAVITGB3ITGA2BITGB6ITGB1 | |
| SCHEMBL7945568 | 0.78 | ITGAV (1.00) | ITGAVITGB3ITGA2BITGB6ITGB8 | |
| SCHEMBL3888492 | 0.78 | ITGAV (1.00) | ITGAVITGB3ITGA2BITGB6ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047425-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | claimed |
| EP-1047425-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-11-02 | — | — | EP | claimed |
| WO-1999030709-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | claimed |