⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5465101 | 0.89 | — | — | |
| SCHEMBL21587313 | 0.84 | NPSR1 (0.30) | — | |
| SCHEMBL3856071 | 0.82 | NPSR1 (0.30) | — | |
| SCHEMBL4555927 | 0.72 | — | — | |
| SCHEMBL5706312 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL3277032 | 0.70 | GAA (0.39) | — | |
| SCHEMBL11788495 | 0.70 | FFAR1 (0.31) | — | |
| SCHEMBL11690149 | 0.70 | NPSR1 (0.31) | — | |
| SCHEMBL21587365 | 0.70 | CD44 (0.35) | — | |
| SCHEMBL2117543 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446387-B1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN CO LLC (US) | 2009-11-04 | — | — | EP | disclosed |
| US-7250418-B2 | Compounds as CRF1 receptor antagonists | PFIZER INC (US) | 2007-07-31 | — | — | US | disclosed |
| US-7041672-B2 | Substituted aryl 1, 4-pyrazine derivatives | PFIZER INC. (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1625125-A1 | COMPOUNDS AS CRF1 RECEPTOR ANTAGONISTS | Pharmacia & Upjohn Company LLC (US) | 2006-02-15 | — | — | EP | disclosed |
| US-6992087-B2 | Substituted aryl 1,4-pyrazine derivatives | PFIZER INC (US) | 2006-01-31 | — | — | US | disclosed |
| US-20050049257-A1 | Substituted aryl 1, 4-pyrazine derivatives | PFIZER INC | 2005-03-03 | — | — | US | disclosed |
| US-20050038040-A1 | Compounds as CRF1 receptor antagonists | PFIZER INC | 2005-02-17 | — | — | US | disclosed |
| WO-2004099201-A1 | COMPOUNDS AS CRF1 RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-11-18 | — | — | WO | disclosed |
| EP-1446387-A1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-18 | — | — | EP | disclosed |
| US-20030144297-A1 | Substituted aryl 1,4-pyrazine derivatives | PHARMACIA & UPJOHN COMPANY | 2003-07-31 | — | — | US | disclosed |
| WO-2003045924-A1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-05 | — | — | WO | disclosed |