SCHEMBL3856071

SCHEMBL3856071

C=CCc1nc(CC=C)c(CC=C)nc1CC=C

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9621343 0.84 XDH (0.31) NPSR1
SCHEMBL3887504 0.82
SCHEMBL5447243 0.82 NPSR1 (0.34) NPSR1
SCHEMBL17961910 0.76
SCHEMBL7601080 0.76 KDM4E (0.32) NPSR1
SCHEMBL5465101 0.76
SCHEMBL9277237 0.72
SCHEMBL20508951 0.72 NPSR1 (0.36) NPSR1
SCHEMBL6556273 0.72 NPSR1 (0.32) NPSR1
SCHEMBL456737 0.71 ALDH1A1 (0.33) NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4865599-A ENHANCING OCCULAR BLOOD FLOW WITH A TETRAALKYLPYRAZINE HOUSTON BIOTECHNOLOGY, INC. (US) 1989-09-12 US claimed
EP-0265042-A2 Ophthalmic compositions comprising a tetraalkyl pyrazine HOUSTON BIOTECHNOLOGY INCORPORATED (US) 1988-04-27 EP claimed
JP-5271652-A None JP disclosed
CN-117511694-A Method for improving content of tetramethylpyrazine in brewing process of mature vinegar 太原学院 2024-02-06 CN disclosed
CN-117511694-A Method for improving content of tetramethylpyrazine in brewing process of mature vinegar 太原学院 2024-02-06 CN disclosed
WO-2023219573-A2 POLYMER ADSORBENTS FOR SELECTIVE IONS ADSORPTION NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2023-11-16 WO disclosed
EP-1237863-B1 N-SUBSTITUTED PERFLUOROALKYLATED PYRROLIDINES, PROCESS FOR MAKING THEM AND PROCESS FOR THE ADDITION OF RF-IODIDE TO AN OLEFIN BASF SE (DE) 2009-09-23 EP disclosed
EP-1237863-A1 N-SUBSTITUTED PERFLUOROALKYLATED PYRROLIDINES, PROCESS FOR MAKING THEM AND PROCESS FOR THE ADDITION OF RF-IODIDE TO AN OLEFIN Ciba SC Holding AG (CH) 2002-09-11 EP disclosed
US-6436235-B1 PREPARED FROM DIALLYLAMINE, PERFLUOROALKYL IODIDE AND AMINO REACTIVE COMPOUND SELECTED FROM CARBOXYLIC ACIDS, ANHYDRIDES, ACID CHLORIDES, OXIRANES, HALOALKANES, ISOCYANATES, UREAS AND METHACRYLICS; SURFACTANTS, OIL PROOFING PAPER AND TEXTILES CIBA SPECIALTY CHEMICALS CORPORATION 2002-08-20 US disclosed
WO-2001028998-A1 N-SUBSTITUTED PERFLUOROALKYLATED PYRROLIDINES, PROCESS FOR MAKING THEM AND PROCESS FOR THE ADDITION OF RF-IODIDE TO AN OLEFIN CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2001-04-26 WO disclosed
US-6121994-A Image forming apparatus and light emitting apparatus CANON KABUSHIKI KAISHA (JP) 2000-09-19 US disclosed
EP-0265042-A3 OPHTHALMIC COMPOSITIONS COMPRISING A TETRAALKYL PYRAZINE HOUSTON BIOTECHNOLOGY INCORPORATED (US) 1990-01-31 EP disclosed
US-4865599-A ENHANCING OCCULAR BLOOD FLOW WITH A TETRAALKYLPYRAZINE HOUSTON BIOTECHNOLOGY, INC. (US) 1989-09-12 US disclosed
US-4859674-A CONTINUOUS INFUSION HOUSTON BIOTECHNOLOGY INCORPORATED (US) 1989-08-22 US disclosed
EP-0265042-A2 Ophthalmic compositions comprising a tetraalkyl pyrazine HOUSTON BIOTECHNOLOGY INCORPORATED (US) 1988-04-27 EP disclosed
EP-0265042-A2 Ophthalmic compositions comprising a tetraalkyl pyrazine HOUSTON BIOTECHNOLOGY INCORPORATED (US) 1988-04-27 EP disclosed
US-4620004-A Polyheterocyclic compounds PHILIP MORRIS INCORPORATED (US) 1986-10-28 US disclosed
EP-0021663-B1 A POLYHETEROCYCLIC COMPOUND, ITS PREPARATION AND A SMOKING COMPOSITION IN WHICH IT IS USED PHILIP MORRIS INCORPORATED (US) 1983-11-16 EP disclosed
US-4318418-A PYRAZINYL COMPOUNDS AS FLAVORANTS PHILIP MORRIS, INCORPORATED (US) 1982-03-09 US disclosed
EP-0021663-A1 A polyheterocyclic compound, its preparation and a smoking composition in which it is used PHILIP MORRIS INCORPORATED (US) 1981-01-07 EP disclosed