Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111852 | 0.83 | MMP2 (0.57) | POLBMAPKAPK2ABCG2ABCB1ADRA1D | |
| SCHEMBL8125346 | 0.82 | MMP2 (0.56) | POLBMAPKAPK2ABCG2ABCB1LMNA | |
| SCHEMBL8123058 | 0.80 | MMP2 (0.54) | POLBMAPKAPK2ABCG2ABCB1ADRA1D | |
| SCHEMBL8111675 | 0.80 | MMP2 (0.54) | POLBMAPKAPK2ABCG2ABCB1ADRA1D | |
| SCHEMBL8121680 | 0.77 | MMP2 (0.65) | POLBMAPKAPK2ABCG2LMNAMMP2 | |
| SCHEMBL8129793 | 0.77 | MMP2 (0.65) | POLBMAPKAPK2ABCG2ABCB1LMNA | |
| SCHEMBL9913669 | 0.77 | ABCG2 (0.72) | ABCG2ABCB1LMNAPKM | |
| SCHEMBL8132615 | 0.76 | MMP2 (0.58) | POLBMAPKAPK2ABCG2ABCB1LMNA | |
| SCHEMBL23438776 | 0.72 | PKM (0.53) | POLBABCG2ABCB1ADRA1DADRA1A | |
| SCHEMBL6465789 | 0.72 | ABCG2 (0.72) | POLBABCG2ABCB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919475-B1 | TETRAHYDRO- BETA-CARBOLIN-SULFONAMIDE DERIVATIVES AS 5-HT6 LIGANDS | ESTEVE LABOR DR (ES) | 2009-03-11 | — | — | EP | claimed |