Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3882808 | 0.75 | KMT2A (0.44) | KDM4EMAPK1ATMSETD7CYP1A2 | |
| SCHEMBL3882223 | 0.70 | PTGIR (0.38) | KDM4EMAPK1ATMSETD7CYP1A2 | |
| SCHEMBL5693983 | 0.70 | MAPK1 (0.61) | KDM4EMAPK1ATMSETD7CYP1A2 | |
| SCHEMBL19537981 | 0.70 | MAPK1 (0.61) | KDM4EMAPK1ATMSETD7CYP1A2 | |
| SCHEMBL10728340 | 0.68 | MAPK1 (0.41) | KDM4EMAPK1ATMSETD7CYP1A2 | |
| SCHEMBL1366285 | 0.68 | HDAC3 (0.61) | KDM4EP2RX4DRD2HDAC3TUBB4A | |
| SCHEMBL30216960 | 0.67 | SIGMAR1 (0.46) | P2RX4DRD2HDAC3TUBB4ATUBB | |
| SCHEMBL2595930 | 0.67 | SIGMAR1 (0.46) | P2RX4DRD2HDAC3TUBB4ATUBB | |
| SCHEMBL2222059 | 0.65 | KDM4E (0.50) | KDM4EMAPK1ATMSETD7CYP1A2 | |
| SCHEMBL2793464 | 0.64 | MAPK1 (0.48) | KDM4EMAPK1ATMSETD7CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686989-B1 | USE OF 1,2-DIAZA-DIBENZO[E,H]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-01-14 | — | — | EP | claimed |