Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1807364 | 0.86 | NAPRT (0.61) | NAPRTTDP1L3MBTL1TSHRLMNA | |
| SCHEMBL25421433 | 0.83 | NAPRT (0.50) | NAPRTTDP1L3MBTL1NPC1TSHR | |
| SCHEMBL12897074 | 0.81 | TSHR (0.59) | NAPRTTDP1L3MBTL1NPC1TSHR | |
| SCHEMBL5325713 | 0.79 | LMNA (0.58) | TDP1L3MBTL1LMNAPOLBKMT2A | |
| SCHEMBL25421430 | 0.79 | ALDH1A1 (0.62) | NAPRTTDP1L3MBTL1NPC1TSHR | |
| SCHEMBL9944381 | 0.78 | NAPRT (0.56) | NAPRTL3MBTL1NPC1LMNAPOLB | |
| SCHEMBL16415899 | 0.78 | NAPRT (0.56) | NAPRTTDP1L3MBTL1NPC1TSHR | |
| SCHEMBL13296381 | 0.76 | TSHR (0.64) | NAPRTTDP1L3MBTL1NPC1TSHR | |
| SCHEMBL29195335 | 0.76 | NAPRT (0.58) | NAPRTTDP1L3MBTL1NPC1TSHR | |
| SCHEMBL1811012 | 0.76 | NAPRT (0.68) | NAPRTTDP1L3MBTL1NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010493-A2 | PYRIDYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120729-A2 | PYRIDYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-10-25 | — | — | WO | disclosed |